Thursday, August 22, 2013

Paracetamol

Paracetamol is a common analgesic and antipyretic drug. It can be purchased over the counter of any medical store without a prescription from a doctor. It is harmless when used at recommended doses (up to 4g / day for adults) and may cause severe damages to liver when consumed in quantities more than recommended. That is why it is not recommended to consume paracetamol without the advise of a doctor.

The molecule shown below is known as acetaminophen and also as paracetamol. Both of the names are derived from its common chemical name para-acetylaminophenol. Its IUPAC Name is N-(4-hydroxyphenyl)acetamide.



Paracetamol can be prepared by nitrating phenol with a mixture of dilute H2SO4 and NaNO3. The nitrogroup is then reduced to amino group and then acylated with acetic anhydride. The scheme of preparation is shown below.

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